Estimated reading time: 8 minutes
What drugs should not be taken with CBD
CBD is gaining popularity at an unprecedented rate, and many people believe that because it has no significant side effects, this non-intoxicating cannabinoid is safe. Cannabidiol, on the other hand, is a powerful agent with the ability to alter biochemistry dramatically, so it’s only natural that it interacts with certain prescription drugs. In most cases, these potential CBD-prescription drug interactions have only mild adverse effects, and you may be happy to know how many prescription drugs CBD does not interact with at all. Suppose you want to or are currently using CBD. In that case, you should be aware of the cannabinoid’s potential to interact with common prescription drugs, as well as what you should do to prevent any unintentional side effects. You might want to know what drugs should not be taken with CBD.
In this article, we will discuss the interaction of CBD oil with other drugs and include a summary of the possible side effects so you can be aware of what drugs should not be taken with CBD.
Let’s get started!
Can you take CBD oil with antidepressants?
All antidepressants go through the CYP450 system in the liver, linked to drug interactions. CBD is a potent inhibitor (agonist) of the CYP2C19 pathway in the CYP450 system.
The good news is that there currently appears to be no proof of a clinically significant relationship between antidepressants and CBD oil.
For the time being, tetrahydrocannabinol, or THC, is the only compound in cannabis that should be monitored for potentially dangerous interactions with antidepressants.
THC ( Tetrahydrocannabinol ), while helpful, is the psychoactive ingredient that causes the “high” of marijuana.
Tetrahydrocannabinol is usually a pleasant sensation, but some psychosis may happen in some people, mainly when used unnecessarily and in large doses.
Tetrahydrocannabinol also binds to endocannabinoid receptors, primarily found in the brain, and has a powerful neurologic effect. Since antidepressants can treat patients through neuronal pathways, interaction with THC is very likely.
CBD, on the other hand, tends to be more stable.
However, it is essential to remember that certain people might be hypersensitive or non-responsive to antidepressants due to a particular enzyme polymorphism.
In layman’s words, “polymorphism” means that specific individuals are genetically predisposed to metabolize antidepressants differently and should probably use CBD products with caution.
Additionally, if you take a selective serotonin reuptake inhibitor (SSRI) such as Prozac, Luvox, or Zoloft, you should be aware of CBD’s neurologic effects.
Does CBD oil interact with blood pressure medications?
Most believe that CBD oil is safe and tolerable drug with little or no recorded side effects.
Although no definitive studies show tangible evidence, it is suggested that CBD oil can affect the efficacy of blood pressure medications in treating hypertension.
Some believe that blood pressure medication, on the other hand, reduces the effectiveness of CBD oil.
Furthermore, since cannabidiol inhibits the cytochrome P-450 enzyme system, CBD oil should be used with caution when combining it with drugs that use this mechanism, specifically metoprolol and amlodipine besylate in high blood pressure medications.
The cytochrome P-450 system comprises liver enzymes that break down drugs into smaller molecules that can be absorbed more easily by the body.
This pathway is slowed by cannabidiol and other naturally occurring compounds, such as grapefruit.
Drugs that rely on the P-450 path, such as metoprolol and amlodipine besylate, may be able to remain in the system for more extended periods, raising the risk of adverse side effects.
CBD oil and omeprazole
There are currently very few reports on CBD’s reactions to omeprazole.
Nonetheless, a few studies show that CBD has almost no effect on omeprazole and its potency.
Although there have been studies to show CBD’s impact on SSRI medications (those that need the P450 enzyme to work), studies on PPI medications like omeprazole are minimal.
Studies show that CBD’s reactions to omeprazole and the results were very positive.
Omeprazole did not affect the responses of CBD within the body, and that its pharmacokinetics were also great.
CBD oil and thyroid medication interactions
The association of cannabinoids and some thyroid drugs happens by competition for metabolism between these compounds.
More specifically, these two compounds compete for cytochrome P450 metabolization.
As a result, since more thyroxine accumulates before the body controls it, this relationship will almost certainly result in hyperthyroidism.
Furthermore, some people have reported mild nausea and anxiety while taking thyroid medication and CBD oil at the same time.
However, allowing a few hours between drugs resulted in no adverse side effects for most people. Of course, the dosage and frequency of use of thyroid drugs and CBD oil are essential considerations.
CBD oil and thyroid medication interactions have no scientific evidence, and thyroid medications such as Levothyroxine are generally safe to consume with CBD.
CBD and statins
Since the severity of side effects in connection with statin drugs is substantially higher than that of other medications, CBD can be a viable alternative for statin users in controlling high cholesterol.
CBD has been shown in several clinical studies to positively impact several bodily functions when it comes to high cholesterol, including liver damage.
Statins helps to reduce cholesterol and lower the risk of developing cardiovascular disease are metabolized by CYP3A4.
As a result, CBD can increase the severity and duration of the effects given by statins, decreasing the likelihood of adverse effects.
Can I take ibuprofen with CBD oil?
Ibuprofen and CBD oil are two options for pain relief, whether you have acute or chronic pain.
Many people opt for one of these two products because they are non-prescription and may provide relief for mild aches and pains.
However, in many cases, a single solution is insufficient, leading users to try a range of solutions to relieve their pain. If you’ve successfully taken CBD and ibuprofen separately, you should have no trouble combining the two.
The two substances have not interacted so far, but that doesn’t mean there won’t be any future.
So, can I take ibuprofen with CBD oil? If you want to optimize pain relief, there is no reason to stop mixing CBD oil and ibuprofen.
However, we advise users to proceed with caution when combining the two drugs for the first time.
CBD side effects
CBD oil is safe to use in general, and there are little to no known CBD side effects.
However, when combined with other drugs, you must proceed with caution. Because it can have adverse effects and always know what drugs should not be taken with CBD.
Depending on the relationship, CBD may either increase or decrease the efficacy of a medication.
If you are already taking some prescription medications, you should check with your doctor before using CBD oil.
You physician can advise you about what drugs should not be taken with CBD.
This medical professional will provide medical advice on the CBD dose that will be effective without causing any adverse side effects.
He/she will also assist you in deciding if the CBD is safe to take.
In some instances, this may include starting with a low dose of CBD and gradually the high doses.
But only do this if you are sure that it is safe to do so.
We hope this what drugs should not be taken with CBD post is helpful to you.
Best of luck in your journey with CBD!